205371-64-8

Upstream product

• 1017935-14-6 N-[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-((2R,3S)-3-tridecyl-oxiranyl)-ethyl]-4-methyl-benzenesulfonamide 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 205371-62-6 N-[(E)-(1S,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-heptadec-3-enyl]-4-methyl-benzenesulfonamide 
• 123-78-4 (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 

Downstream Products

• 205371-68-2 (2S,3S,4R)-3,4-di-O-tertbutyldimethylsilyl-2-(N-hexacosanoylamino)octadecan-1,3,4-triol 
• 1044255-87-9 C₃₇H₇₁NO₅SSi₂ 
• 908848-04-4 (2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine 
• 908848-10-2 C₈₄H₁₃₅NO₈Si 
• 908848-09-9 C₈₄H₁₃₅NO₈Si 

Relevant academic research and scientific papers

Diastereoselective epoxidation of the double bond at C-4 of sphingosines to provide phytosphingosine relatives such as α-galactosylceramide KRN7000

Diastereoselective epoxidation of the double bond at C-4 of two sphingosine derivatives [3, R = (CH2)7Me or (CH2)12Me] was studied. Dimethyldioxirane was found to be the best oxidant for that purpose. Application of this epoxidation resulted in a new synthesis of the α- galactosylceramide KRN7000 (2), which has an enhancing effect on the activity of natural killer cells.