N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Base Information

Chemical Name:N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide
CAS No.:1103232-26-3
Molecular Formula:C₁₇H₁₈F₂N₄O₄S
Molecular Weight:412.417
Hs Code.:

Synonyms:N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Suppliers and Price of N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

There total 7 articles about N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.0%

: 10147-36-1
n-propanesulfonyl chloride

: 1103234-47-4
N-(6-acetylamino-3-pyridyl)-3-amino-2,6-difluorobenzamide

: 1103232-26-3
N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Guidance literature:: With pyridine; dmap; In pyridine; at 20 - 70 ℃; for 90h;

Reference yield:

: 29958-14-3
N-(5-aminopyridin-2-yl)acetamide

: 1186194-32-0
2,6-difluoro-3-(propylsulfonamido)benzoyl chloride

: 1103232-26-3
N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide; Reflux;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1103232-26-3
N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol

2: triethylamine / dichloromethane / 20 °C / Cooling

3: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C

4: thionyl chloride / toluene / 6 h / Reflux

5: N-ethyl-N,N-diisopropylamine / chloroform; N,N-dimethyl-formamide / Reflux

With thionyl chloride; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;