2-Acetamido-5-aminopyridine

Base Information

• Chemical Name: 2-Acetamido-5-aminopyridine
• CAS No.: 29958-14-3
• Molecular Formula: C7H9N3O
• Molecular Weight: 151.168
• Hs Code.: 29333990
• European Community (EC) Number: 626-281-5
• DSSTox Substance ID: DTXSID10370620
• Nikkaji Number: J3.575.961A
• Wikidata: Q72433984
• Mol file: 29958-14-3.mol

Synonyms:2-acetamido-5-aminopyridine

Chemical Property of 2-Acetamido-5-aminopyridine

Chemical Property:

• Vapor Pressure: 0.000342mmHg at 25°C
• Melting Point: 154-158 °C(lit.)
• Refractive Index: 1.646
• Boiling Point: 319.3 °C at 760 mmHg
• PKA: 13.44±0.70(Predicted)
• Flash Point: 146.9 °C
• PSA: 68.01000
• Density: 1.28 g/cm³
• LogP: 1.27640
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.074561919
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Acetamido-5-aminopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(C=C1)N
• Uses: 2-Acetamido-5-Aminopyridine is used in preparation of bicyclic heteroaryl compounds as CRBN protein regulators.

Technology Process of 2-Acetamido-5-aminopyridine

There total 6 articles about 2-Acetamido-5-aminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-acetamido-5-nitropyridine (5093-64-1) → N-(5-aminopyridin-2-yl)acetamide (29958-14-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3.5h;

DOI:10.1055/s-1989-27427

Reference yield: 98.0%

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) → N-(5-aminopyridin-2-yl)acetamide (29958-14-3) + 2-acetamido-5-nitropyridine (5093-64-1)

Guidance literature:

With sulfuric acid; In acetic anhydride;

Reference yield: 20.0%

methanol (67-56-1) + 2-acetamido-5-nitropyridine (5093-64-1) → N-(5-aminopyridin-2-yl)acetamide (29958-14-3)

Guidance literature:

In ethanol; chloroform;

upstream raw materials:

2-acetamido-5-nitropyridine

5-nitro-pyridin-2-ylamine

methanol

Refernces

• 1、 -. "Pyridines IRAK4 inhibitors, preparation method and application thereof (by machine translation)". Paragraph 0097; 0098; 0099. . Retrieved 2017/09/01.
• 2、 -. "INHIBITORS OF HEPATITIS C VIRUS REPLICATION". Page/Page column 65. . Retrieved 2010/11/04.