ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride

Base Information

• Chemical Name: ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride
• CAS No.: 1101167-64-9
• Molecular Formula: C₃₁H₃₃N₃O₅*ClH
• Molecular Weight: 564.081
• Mol file: 1101167-64-9.mol

Synonyms:ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride

Chemical Property of ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride

There total 1 articles about ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride → ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride (1101167-64-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 1h;

DOI:10.1002/anie.200803298

Reference yield: 79.0%

(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoic acid (1025368-73-3) + ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride (1101167-64-9) → ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate (1025370-27-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/anie.200803298

Downstream raw materials:

ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate