ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate

Base Information

• Chemical Name: ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate
• CAS No.: 1025370-27-7
• Molecular Formula: C₄₈H₆₀N₄O₈
• Molecular Weight: 821.026
• Mol file: 1025370-27-7.mol

Synonyms:ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate

Chemical Property of ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate

There total 2 articles about ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoic acid (1025368-73-3) + ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride (1101167-64-9) → ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate (1025370-27-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/anie.200803298

Reference yield:

ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride (259214-54-5,259214-56-7) + (4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-proline (1025370-24-4) → ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate (1025370-27-7)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 66.0%

ethyl (1R,2S)-1-({(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate (1025370-27-7) → ethyl (3R,6S,9R,11S,12Z,19S,26E)-29-methoxy-24,24-dimethyl-7,21,37-trioxo-33-phenyl-2,22-dioxa-5,8,20,32-tetraazahexacyclo[26.6.2.1(3,6).1(5,19).0(9,11).0(31,35)]octatriaconta-1(34),12,26,28,30,32,35-heptaene-9-carboxylate

Guidance literature:

With 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; In 1,2-dichloro-ethane; at 70 ℃; for 1h; chemoselective reaction;

DOI:10.1002/anie.200803298

upstream raw materials:

ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

(4R)-1-[(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoyl]-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-proline

(2S)-2-({[(2,2-dimethylpent-4-en-1-yl)oxy]carbonyl}amino)non-8-enoic acid

ethyl (1R,2S)-1-({(4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]-L-prolyl}amino)-2-vinylcyclopropanecarboxylate hydrochloride

Downstream raw materials:

ethyl (3R,6S,9R,11S,12Z,19S,26E)-29-methoxy-24,24-dimethyl-7,21,37-trioxo-33-phenyl-2,22-dioxa-5,8,20,32-tetraazahexacyclo[26.6.2.13,6.15,19.09,11.031,35]octatriaconta-1⁽³⁵⁾,12,26,28,30,31,33,35-octaene-9-carboxylate