C₁₅H₈Cl₂N₂O₄

Base Information

• Chemical Name: C₁₅H₈Cl₂N₂O₄
• CAS No.: 1251583-13-7
• Molecular Formula: C₁₅H₈Cl₂N₂O₄
• Molecular Weight: 351.146
• Mol file: 1251583-13-7.mol

Synonyms:C₁₅H₈Cl₂N₂O₄

Chemical Property of C₁₅H₈Cl₂N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₈Cl₂N₂O₄

There total 1 articles about C₁₅H₈Cl₂N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-dichloro-2-hydroxy-benzonitrile (3336-32-1) + 4-Nitrophenacyl bromide (99-81-0) → C15H8Cl2N2O4 (1251583-13-7)

Guidance literature:

With sodium carbonate; In acetone; for 18h; Reflux;

Reference yield: 95.0%

C15H8Cl2N2O4 (1251583-13-7) + chloroformic acid ethyl ester (541-41-3) → C18H12Cl2N2O6 (1251583-16-0)

Guidance literature:

With potassium carbonate; In toluene; for 18h; Inert atmosphere; Reflux;

Reference yield:

C15H8Cl2N2O4 (1251583-13-7) → C26H26Cl2N4O3 (1251590-84-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / toluene / 18 h / Inert atmosphere; Reflux

2.1: hydrogenchloride; tin / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

3.1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 3 h / 20 °C

4.1: caesium carbonate / dimethyl sulfoxide / 0.08 h / 20 °C

4.2: 0.75 h / 45 °C

5.1: ammonium acetate / 5 h / 130 °C

6.1: potassium phosphate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,2-dimethoxyethane / 6 h / 100 °C / Inert atmosphere

With hydrogenchloride; tin; potassium phosphate; tert.-butylnitrite; ammonium acetate; potassium carbonate; caesium carbonate; copper(ll) bromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; toluene; acetonitrile;

upstream raw materials:

3,5-dichloro-2-hydroxy-benzonitrile

4-Nitrophenacyl bromide

Downstream raw materials:

C₁₈H₁₂Cl₂N₂O₆

C₂₆H₂₆Cl₂N₄O₃