benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

Base Information

Chemical Name:benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide
CAS No.:115095-92-6
Molecular Formula:C₂₁H₂₀ClNO₄S
Molecular Weight:417.913
Hs Code.:

Synonyms:benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

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Chemical Property of benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

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Technology Process of benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

There total 8 articles about benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 115095-91-5
benzhydryl 2α-(chloromethyl)-2β-methyl-6α-bromopenam-3α-carboxylate 1β-oxide

: 115095-92-6
benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

Guidance literature:: With acetic acid; zinc; In acetonitrile; at 10 ℃; for 2h;
DOI:10.1021/jo00251a025

Reference yield:

: 115095-90-4
benzhydryl 2α-(chloromethyl)-2β-methyl-6-diazopenam-3α-carboxylate 1β-oxide

: 115095-92-6
benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 63.8 percent / HBr / ethyl acetate / 0.5 h / 0 °C

2: 47.6 percent / glacial acetic acid, Zn / acetonitrile / 2 h / 10 °C

With hydrogen bromide; acetic acid; zinc; In ethyl acetate; acetonitrile;
DOI:10.1021/jo00251a025

Reference yield:

: 51415-50-0
benzhydryl 2β-(chloromethyl)-2α-methyl-6β-(phenylacetamido)penam-3α-carboxylate

: 115095-92-6
benzhydryl 2α-(chloromethyl)-2β-methyl-6,6-dihydropenam-3α-carboxylate 1β-oxide

Guidance literature:: Multi-step reaction with 8 steps

1: CH₃COONa, N₂O₄ / CH₂Cl₂ / 1 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 0.67 h / Ambient temperature

3: glacial acetic acid, Zn / CH₂Cl₂ / 1 h

4: 50 percent / toluene / 0.5 h / Heating

5: CH₃COONa, N₂O₄ / CH₂Cl₂ / 1 h

6: pyridine / CH₂Cl₂ / 3 h / Heating

7: 63.8 percent / HBr / ethyl acetate / 0.5 h / 0 °C

8: 47.6 percent / glacial acetic acid, Zn / acetonitrile / 2 h / 10 °C

With pyridine; hydrogen bromide; sodium acetate; dinitrogen tetraoxide; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; In dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jo00251a025