N-Methyl-2-indolyldimethylsilanol

Base Information

• Chemical Name: N-Methyl-2-indolyldimethylsilanol
• CAS No.: 784161-65-5
• Molecular Formula: C11H15 N O Si
• Molecular Weight: 205.332
• DSSTox Substance ID: DTXSID60478185
• Nikkaji Number: J2.101.871F
• Wikidata: Q82311411
• Mol file: 784161-65-5.mol

Synonyms:784161-65-5;N-METHYL-2-INDOLYLDIMETHYLSILANOL;hydroxy-dimethyl-(1-methylindol-2-yl)silane;Dimethyl(1-methyl-1H-indol-2-yl)silanol;DTXSID60478185;Silanol,dimethyl(1-methyl-1H-indol-2-yl)-(9ci)

Chemical Property of N-Methyl-2-indolyldimethylsilanol

Chemical Property:

• PSA: 25.16000
• LogP: 1.58270
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 205.092290636
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

N-METHYL-2-INDOLYLDIMETHYLSILANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C=C1[Si](C)(C)O

Technology Process of N-Methyl-2-indolyldimethylsilanol

There total 1 articles about N-Methyl-2-indolyldimethylsilanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-methylindole (603-76-9) + Hexamethylcyclotrisiloxane (541-05-9) → 2-(hydroxydimethylsilyl)-1-methyl-1H-indole (784161-65-5)

Guidance literature:

1-methylindole; With n-butyllithium; In diethyl ether; hexane; for 5h; Heating;

Hexamethylcyclotrisiloxane; In diethyl ether; hexane; at 0 - 20 ℃; for 12h;

DOI:10.1021/ol048328a

Reference yield: 84.0%

para-nitrophenyl bromide (586-78-7) + 2-(hydroxydimethylsilyl)-1-methyl-1H-indole (784161-65-5) → 1-methyl-2-(4-nitrophenyl)-1H-indole + 1-methyl-2,3-bis(4-nitrophenyl)-1H-indole

Guidance literature:

para-nitrophenyl bromide; With copper(l) iodide; 1,4-di(diphenylphosphino)-butane; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; for 0.166667h;

2-(hydroxydimethylsilyl)-1-methyl-1H-indole; In toluene; at 55 ℃; for 20h;

DOI:10.1021/ol048328a

Reference yield: 82.0%

iodobenzene (591-50-4) + 2-(hydroxydimethylsilyl)-1-methyl-1H-indole (784161-65-5) → 1-methyl-2-phenyl-1H-indole (3558-24-5)

Guidance literature:

iodobenzene; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; sodium t-butanolate; In toluene; for 0.166667h;

2-(hydroxydimethylsilyl)-1-methyl-1H-indole; In toluene; at 20 ℃; for 3h;

DOI:10.1021/ol048328a

upstream raw materials:

1-methylindole

Hexamethylcyclotrisiloxane

Downstream raw materials:

1-methyl-2-phenyl-1H-indole

N-methyl-2-(4-methoxyphenyl)indole

4-(1-methyl-1H-indol-2-yl)benzonitrile