N-Boc-2-indolyldimethylsilanol

Base Information

Chemical Name:N-Boc-2-indolyldimethylsilanol
CAS No.:784161-48-4
Molecular Formula:C15H21 N O3 Si
Molecular Weight:291.422
Hs Code.:2933990090
European Community (EC) Number:676-855-4
DSSTox Substance ID:DTXSID00478184
Nikkaji Number:J2.101.870H
Wikidata:Q82311410
Mol file:784161-48-4.mol

Synonyms:784161-48-4;N-Boc-2-indolyldimethylsilanol;N-(BOC)-2-INDOLYLDIMETHYLSILANOL;1-Boc-2-indolyldimethylsilanol;tert-butyl 2-[hydroxy(dimethyl)silyl]indole-1-carboxylate;DTXSID00478184;1-Boc-2-indolyldimethylsilanol,95%;MFCD08457643;N-Boc-2-indolyldimethylsilanol, 95%

Suppliers and Price of N-Boc-2-indolyldimethylsilanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
N-Boc-2-indolyldimethylsilanol 95%
5g
$ 332.00

Sigma-Aldrich
N-Boc-2-indolyldimethylsilanol 95%
1g
$ 114.00

American Custom Chemicals Corporation
N-BOC-2-INDOLYLDIMETHYLSILANOL 95.00%
5G
$ 1222.45

American Custom Chemicals Corporation
N-BOC-2-INDOLYLDIMETHYLSILANOL 95.00%
1G
$ 126.30

Total 4 raw suppliers

Chemical Property of N-Boc-2-indolyldimethylsilanol

Chemical Property:

Vapor Pressure:4.94E-07mmHg at 25°C
Refractive Index:n20/D 1.545
Boiling Point:397.5°C at 760 mmHg
Flash Point:>110°C
PSA：51.46000
Density:1.08g/cm³
LogP:2.82890
Storage Temp.:2-8°C
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:291.12907007
Heavy Atom Count:20
Complexity:378

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-2-indolyldimethylsilanol 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1C2=CC=CC=C2C=C1[Si](C)(C)O
Uses N-Boc-2-indolyldimethylsilanol is a useful silicon nucleophile for Pd-catalyzed cross-coupling.4 Reactant for:Palladium-catalyzed cross-coupling reactions

Technology Process of N-Boc-2-indolyldimethylsilanol

There total 1 articles about N-Boc-2-indolyldimethylsilanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 75400-67-8
indole-1-carboxylic acid tert-butyl ester

: 75-78-5,30107-43-8
dimethylsilicon dichloride

: 784161-48-4
2-(hydroxydimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 18h;
DOI:10.1021/ol048328a

Reference yield: 93.0%

: 636-98-6
p-nitrobenzene iodide

: 784161-48-4
2-(hydroxydimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

: 193810-88-7
2-(4-nitrophenyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With sodium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 20 ℃; for 12h;
DOI:10.1021/jo7023784

Reference yield: 84.0%

: 636-98-6
p-nitrobenzene iodide

: 784161-48-4
2-(hydroxydimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

: 1528-74-1
4,4'-dinitrobiphenyl

: 193810-88-7
2-(4-nitrophenyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Guidance literature:: p-nitrobenzene iodide; With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; sodium t-butanolate; In toluene; for 0.166667h;

2-(hydroxydimethylsilyl)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; In toluene; at 20 ℃; for 6h;
DOI:10.1021/ol048328a