6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Base Information

• Chemical Name: 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
• CAS No.: 784150-41-0
• Molecular Formula: C6H3BrClN3
• Molecular Weight: 232.467
• Hs Code.: 2933990090
• Mol file: 784150-41-0.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine,6-bromo-4-chloro- (9CI);7H-pyrrolo[2,3-d]pyrimidine, 6-bromo-4-chloro-;6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine;

Chemical Property of 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Chemical Property:

• Refractive Index: 1.746
• PKA: 9.52±0.50(Predicted)
• PSA: 41.57000
• Density: 1.996 g/cm³
• LogP: 2.37380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE

There total 1 articles about 6-BROMO-4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-bromo-4-chloro-7-(benzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (784150-40-9) → 6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (784150-41-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 16h;

Reference yield: 69.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (784150-41-0) → C32H23BrClN3O7

Guidance literature:

6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2019.03.024

Reference yield: 60.0%

6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (784150-41-0) + methyl iodide (74-88-4) → 6-bromo-4-chloro-7-methylpyrrolo[2,3-d]pyrimidine (784150-42-1)

Guidance literature:

6-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; for 16h;

upstream raw materials:

6-bromo-4-chloro-7-(benzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

6-bromo-4-chloro-7-methylpyrrolo[2,3-d]pyrimidine

C₁₂H₈BrN₃O₂

6-({6-[(4-chlorophenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-1,3-benzothiazol-2(3H)-one

N-methyl-3-[(6-phenyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzenesulfonamide