Technology Process of (+)-MCL-740
There total 6 articles about (+)-MCL-740 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
[(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate; potassium carbonate;
In
tert-butyl alcohol;
at 110 ℃;
for 1.5h;
Sealed tube;
Inert atmosphere;
DOI:10.1021/cn400205z
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / chloroform / 70 °C
2: hydrogenchloride; acetic acid / water / 90 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: potassium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate / tert-butyl alcohol / 1.5 h / 110 °C / Sealed tube; Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate; potassium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; dichloromethane; chloroform; water; tert-butyl alcohol;
DOI:10.1021/cn400205z
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride; acetic acid / water / 90 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: potassium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate / tert-butyl alcohol / 1.5 h / 110 °C / Sealed tube; Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate; potassium carbonate; acetic acid; triethylamine;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/cn400205z
