6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

Base Information

Chemical Name:6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]
CAS No.:853019-28-0
Molecular Formula:C₂₆H₃₁N₃O₅S
Molecular Weight:497.615
Hs Code.:

Synonyms:6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

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Chemical Property of 6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

Chemical Property:

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Technology Process of 6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

There total 4 articles about 6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-97-4
2-(methylsulfonyl)acetic acid

: 853020-95-8,853018-33-4
6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853019-28-0
6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

Guidance literature:: With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 40h;

Reference yield:

: 66-83-1
5-methoxytryptamine hydrochloride

: 853019-28-0
6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 100 °C

1.2: 72 h

2.1: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

3.1: diisopropyl-carbodiimide / dichloromethane / 40 h / 20 °C

With potassium carbonate; acetic acid; diisopropyl-carbodiimide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 853020-88-9,853020-89-0,853020-91-4
1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

: 853019-28-0
6-methoxy-2-[(methylsulfonyl)acetyl]-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: potassium carbonate / methanol; acetonitrile / 2 h / 70 °C

3: diisopropyl-carbodiimide / dichloromethane / 40 h / 20 °C

With hydrogen; potassium carbonate; diisopropyl-carbodiimide; palladium dihydroxide; In methanol; dichloromethane; water; acetonitrile;