2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel
CAS No.:175917-94-9
Molecular Formula:C₅₆H₈₃NO₁₅Si₂
Molecular Weight:1066.44
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

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Chemical Property of 2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

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Technology Process of 2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

There total 4 articles about 2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 115437-21-3
7-(triethylsilyl)baccatin III

: 175917-91-6
(3R,4R)-3-<(tert-butyldimethylsilyl)oxy>-4-(2-furyl)-1-hexanoyl-2-azetidinone

: 175917-94-9
2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -41 ℃; for 0.166667h;
DOI:10.1021/jo951961c

Reference yield:

: 994-30-9
triethylsilyl chloride

: 175917-94-9
2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / pyridine / 12 h / Ambient temperature

2: 46 percent / NaHMDS / tetrahydrofuran / 0.17 h / -41 °C

With pyridine; sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo951961c

Reference yield:

: 27548-93-2
baccatin III

: 175917-94-9
2'-O-(tert-butyldimethylsilyl)-N-debenzoyl-3'-dephenyl-3'-(2-furyl)-N-hexanoyl-7-O-(triethylsilyl)paclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / pyridine / 12 h / Ambient temperature

2: 46 percent / NaHMDS / tetrahydrofuran / 0.17 h / -41 °C

With pyridine; sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jo951961c