(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid
CAS No.:1445591-92-3
Molecular Formula:C₁₅H₁₅BrN₂O₂
Molecular Weight:335.2
Hs Code.:

Synonyms:(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

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Chemical Property of (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Chemical Property:

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Technology Process of (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

There total 7 articles about (1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1445591-91-2
(1R,2R)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

: 1445591-92-3
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Guidance literature:: With hydrogenchloride; In water; at 80 ℃; for 2h;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1445591-92-3
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / chloroform / 0 - 20 °C

1.2: 6 h / 0 °C

1.3: pH 5

2.1: acetic anhydride / 20 h / Reflux

3.1: quinine / toluene; tetrachloromethane / 60 h / -65 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

5.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

6.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

7.1: hydrogenchloride / water / 2 h / 80 °C

With hydrogenchloride; ammonium acetate; bromine; acetic anhydride; quinine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; chloroform; water; toluene; acetonitrile;

Reference yield:

: 35878-28-5,743438-34-8
cyclopentane-cis-1,2-dicarboxylic acid anhydride

: 1445591-92-3
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: quinine / toluene; tetrachloromethane / 60 h / -65 °C

2: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

3: acetonitrile / 5 h / 20 °C / Inert atmosphere

4: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

5: hydrogenchloride / water / 2 h / 80 °C

With hydrogenchloride; ammonium acetate; quinine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; water; toluene; acetonitrile;