2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Base Information

Chemical Name:2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide
CAS No.:1262278-66-9
Molecular Formula:C₂₄H₃₀N₄O₂
Molecular Weight:406.528
Hs Code.:

Synonyms:2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

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Chemical Property of 2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

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Technology Process of 2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

There total 7 articles about 2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 868072-17-7
2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

: 4399-47-7
Bromocyclobutane

: 1262278-66-9
2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 120h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.02.004

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1262278-66-9
2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 72 h / Inert atmosphere; Reflux

2: sodium hydride / toluene / 18 h / 80 °C / Inert atmosphere

3: sodium hydride / tetrahydrofuran / 27 h / 0 - 20 °C / Inert atmosphere

4: hydrazine hydrate; acetic acid / ethanol / 13 h / Inert atmosphere; Reflux

5: ethanol / 20 h / Inert atmosphere; Reflux

6: aluminum (III) chloride / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

7: potassium carbonate / N,N-dimethyl-formamide / 120 h / 40 °C / Inert atmosphere

With aluminum (III) chloride; hydrazine hydrate; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.ejmech.2015.02.004

Reference yield:

: 35826-59-6
methyl 4-isopropoxybenzoate

: 1262278-66-9
2-(2-(4-cyclobutoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / toluene / 18 h / 80 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 27 h / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate; acetic acid / ethanol / 13 h / Inert atmosphere; Reflux

4: ethanol / 20 h / Inert atmosphere; Reflux

5: aluminum (III) chloride / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 120 h / 40 °C / Inert atmosphere

With aluminum (III) chloride; hydrazine hydrate; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2015.02.004