2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

Base Information

Chemical Name:2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide
CAS No.:1384517-66-1
Molecular Formula:C₂₃H₃₀N₄O₂
Molecular Weight:394.517
Hs Code.:

Synonyms:2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

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Chemical Property of 2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

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Technology Process of 2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

There total 8 articles about 2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1384517-65-0
2-[3-amino-5-(4-isopropoxyphenyl)-1H-pyrazol-4-yl]-N,N-diethylacetamide

: 123-54-6,81235-32-7
acetylacetone

: 1384517-66-1
2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

Guidance literature:: In ethanol; for 20h; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.05.044

Reference yield: 90.6%

: C₁₈H₂₆N₄O₂

: 123-54-6,81235-32-7
acetylacetone

: 1384517-66-1
2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

Guidance literature:: In ethanol; Reflux;
DOI:10.1016/j.bmc.2019.07.036

Reference yield:

: 884504-22-7
3-(4-isopropoxyphenyl)-3-oxopropanenitrile

: 1384517-66-1
2-[2-(4-isopropoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 13 h / Inert atmosphere; Reflux

2.1: ethanol / 20 h / Reflux; Inert atmosphere

With sodium hydride; In tetrahydrofuran; ethanol; mineral oil;
DOI:10.1016/j.tetlet.2012.05.044