(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

Base Information

Chemical Name:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne
CAS No.:1403989-47-8
Molecular Formula:C₃₁H₄₃N₃O₇
Molecular Weight:569.698
Hs Code.:

Synonyms:(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

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Chemical Property of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

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Technology Process of (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

There total 6 articles about (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403989-45-6
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-prop-2-yne

: 30388-20-6
N,N,N',N',N'',N''-hexamethylguanidinium chloride

: 1403989-47-8
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

Guidance literature:: (1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]decan-5-yl]-1-methoxy-prop-2-yne; With n-butyllithium; In tetrahydrofuran; hexane; at -40 - 20 ℃;

N,N,N',N',N'',N''-hexamethylguanidinium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 168h; Inert atmosphere;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 1403989-38-7
C₂₁H₂₄O₈

: 1403989-47-8
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / Reflux

2.1: toluene; tetrahydrofuran / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

4.2: 168 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene; paraffin oil; 2.1: |Grignard Reaction;
DOI:10.5560/ZNB.2012-0108

Reference yield:

: 143616-91-5
(1S,3S,5R,6R,8R)-5-<(1R)-1,2-Dihydroxyethyl>-3,8-di(4-methoxyhenyl)-2,4,7,9-tetraoxabicyclo<4.4.0>decane

: 1403989-47-8
(1R)-1-[(1S,3S,5R,6R,8R)-3,8-bis(4-methoxyphenyl)-2,4,7,9-tetraoxabicyclo[4.4.0]-decan-5-yl]-1-methoxy-4,4,4-tris(dimethylamino)but-2-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate / 1,4-dioxane; water / 48 h / 20 °C

2.1: toluene; tetrahydrofuran / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 3 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / -40 - 20 °C

4.2: 168 h / 20 °C / Inert atmosphere

With sodium periodate; n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; toluene; paraffin oil; 2.1: |Grignard Reaction;
DOI:10.5560/ZNB.2012-0108