2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate

Base Information

• Chemical Name: 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate
• CAS No.: 57931-91-6
• Molecular Formula: C₂H₂O₄*C₁₈H₂₁NO₃S
• Molecular Weight: 421.471
• Mol file: 57931-91-6.mol

Synonyms:2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate

Chemical Property of 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate

There total 10 articles about 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid (40828-46-4) + 2-(dimethylamino)ethyl chloride (107-99-3) → 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate (57931-91-6)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; In methanol; chloroform; water; isopropyl alcohol; benzene;

Reference yield:

4-(1-chloro-ethyl)-benzoyl chloride → 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate (57931-91-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / tin(IV) chloride / thiophene; dichloromethane

2: dimethyl sulfoxide

3: sulfuric acid; acetic acid / petroleumether; water

4: N,N,N,N,N,N-hexamethylphosphoric triamide / methanol; chloroform; water; isopropyl alcohol; benzene

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; acetic acid; tin(IV) chloride; In thiophene; methanol; petroleumether; dichloromethane; chloroform; water; dimethyl sulfoxide; isopropyl alcohol; benzene;

Reference yield:

(4-bromomethyl-phenyl)-thiophen-2-yl-methanone (52841-35-7) → 2-(dimethylamino)ethyl p-(2-thenoyl)hydratropate oxalate (57931-91-6)

Guidance literature:

Multi-step reaction with 4 steps

1: petroleumether; dimethyl sulfoxide

2: sulfuric acid; acetic acid / ice-water; petroleumether; chloroform; water

3: ammonia; sodium; iron(III) chloride / petroleumether; diethyl ether

4: N,N,N,N,N,N-hexamethylphosphoric triamide / methanol; chloroform; water; isopropyl alcohol; benzene

With N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; ammonia; sodium; iron(III) chloride; acetic acid; In methanol; ice-water; petroleumether; diethyl ether; chloroform; water; dimethyl sulfoxide; isopropyl alcohol; benzene;

upstream raw materials:

2-[4-(thien-2-ylcarbonyl)phenyl]propanoic acid

2-(dimethylamino)ethyl chloride

2-(4-fluorobenzoyl)thiophene

[4-(thiophene-2-carbonyl)-phenyl]-acetonitrile