{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

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Chemical Name:{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester
CAS No.:201355-49-9
Molecular Formula:C₂₉H₄₆N₆O₅
Molecular Weight:558.721
Hs Code.:

Synonyms:{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

There total 10 articles about {(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 201355-48-8
C₂₉H₄₅N₇O₇

: 201355-49-9
{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; ethyl acetate; under 2585.7 Torr;
DOI:10.1016/S0960-894X(98)00636-2

Reference yield:

: 74411-97-5
3(S)-[(tert-butyloxycarbonyl)amino]-2-oxo-1-piperidineacetic acid

: 201355-49-9
{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 96 percent / K₂CO₃ / dimethylformamide; acetonitrile / Heating

2: 100 percent / 5 N aq. HCl / ethyl acetate / 3 h / Ambient temperature

3: 70 percent / Na(OAc)3BH, Et₃N, DCE / Ambient temperature

4: NaHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

5: LiN(TMS)2 / tetrahydrofuran / 0 - 20 °C

6: 96 percent / HCl / ethanol / 0 - 20 °C

7: 69 percent / Na(OAc)3BH, Et₃N / Ambient temperature

8: 1.) NaHCO₃, 2.) aq. LiOH, 3.) Dowex H⁺

9: 71 percent / EDC, HOBt, DIPEA / acetonitrile / 18 h / Ambient temperature

10: 100 percent / H₂ / Pd/C / ethanol; ethyl acetate; H₂O / 2585.7 Torr

With hydrogenchloride; lithium hydroxide; DCE; Dowex H⁺; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(98)00636-2

Reference yield:

: 95582-22-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

: 201355-49-9
{(S)-1-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-phenethyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / HCl / ethanol / 0 - 20 °C

2: 69 percent / Na(OAc)3BH, Et₃N / Ambient temperature

3: 1.) NaHCO₃, 2.) aq. LiOH, 3.) Dowex H⁺

4: 71 percent / EDC, HOBt, DIPEA / acetonitrile / 18 h / Ambient temperature

5: 100 percent / H₂ / Pd/C / ethanol; ethyl acetate; H₂O / 2585.7 Torr

With hydrogenchloride; lithium hydroxide; Dowex H⁺; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0960-894X(98)00636-2