(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

Base Information

Chemical Name:(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester
CAS No.:95582-22-2
Molecular Formula:C₁₅H₂₆N₂O₅
Molecular Weight:314.382
Hs Code.:

Synonyms:(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

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Chemical Property of (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

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Technology Process of (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

There total 1 articles about (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 95582-22-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

2: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

With sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm960572n

Reference yield:

: 95582-22-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

: 201355-27-3
N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / HCl / ethyl acetate / 0 - 20 °C

2: Et₃N / acetonitrile / 0 - 20 °C

3: 95 percent / aq. LiOH / ethanol / 0 - 20 °C

4: EDC, HOBt, DIPEA / acetonitrile

5: 100 percent / H₂, aq. AcOH / Pd/C / ethanol / 2327.2 - 3102.9 Torr

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n

Reference yield:

: 95582-22-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

: CVS 1778

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / HCl / ethyl acetate / 0 - 20 °C

2: Et₃N / acetonitrile / 0 - 20 °C

3: 95 percent / aq. LiOH / ethanol / 0 - 20 °C

4: EDC, HOBt, DIPEA / acetonitrile

5: 100 percent / H₂, aq. AcOH / Pd/C / ethanol / 2327.2 - 3102.9 Torr

6: 3 N HCl / 4 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n