3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene

Base Information

• Chemical Name: 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene
• CAS No.: 133295-95-1
• Molecular Formula: C₂₃H₁₃F₄N₃O₃S
• Molecular Weight: 487.434

Synonyms:3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene

Chemical Property of 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene

Chemical Property:

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Technology Process of 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene

There total 3 articles about 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-Azido-2,3,5,6-tetrafluorobenzoyl Chloride (122590-78-7) + 2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene (133295-95-1)

Guidance literature:

With aluminium trichloride; titanium tetrachloride; In dichloromethane; at 25 ℃; for 24h;

DOI:10.1021/jo00009a037

Reference yield:

4-amino-2,3,5,6-tetrafluorobenzoic acid (944-43-4) → 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene (133295-95-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaNO₂; 2.) NaN₃ / 1.) TFA, 0 deg C, 0.5 h; 2.) Et₂O, 1 h

2: 100 percent / PCl₅ / diethyl ether / 0.17 h

3: 48 percent / AlCl₃, TiCl₄ / CH₂Cl₂ / 24 h / 25 °C

With aluminium trichloride; sodium azide; phosphorus pentachloride; titanium tetrachloride; sodium nitrite; In diethyl ether; dichloromethane;

DOI:10.1021/jo00009a037

Reference yield:

4-azido-2,3,5,6-tetrafluorobenzoic acid (122590-77-6) → 3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene (133295-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / PCl₅ / diethyl ether / 0.17 h

2: 48 percent / AlCl₃, TiCl₄ / CH₂Cl₂ / 24 h / 25 °C

With aluminium trichloride; phosphorus pentachloride; titanium tetrachloride; In diethyl ether; dichloromethane;

DOI:10.1021/jo00009a037

upstream raw materials:

4-Azido-2,3,5,6-tetrafluorobenzoyl Chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

4-amino-2,3,5,6-tetrafluorobenzoic acid

4-azido-2,3,5,6-tetrafluorobenzoic acid

Downstream raw materials:

3-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-6-hydroxy-2-(4-hydroxyphenyl)benzothiophene

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