[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester
CAS No.:1386985-84-7
Molecular Formula:C₁₈H₂₄F₃N₃O₃
Molecular Weight:387.402
Hs Code.:

Synonyms:[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

There total 6 articles about [5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₂F₃N₅O₃

: 1386985-84-7
[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In ethanol; at 20 ℃; for 1h; under 825.083 Torr;

Reference yield:

: 1386985-81-4
N-[1-(5-bromo-2-fluoro-phenyl)-2-(cyano-bis-fluoromethyl-methoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

: 1386985-84-7
[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; N-Acetylcysteine / ethanol / 16 h / Reflux

2: dichloromethane / 16 h / 20 °C

3: sodium azide; copper(l) iodide; sodium L-ascorbate; trans-N,N'-dimethylcyclohexane-1,2-diamine / ethanol; water / 0.75 h / 70 °C / Inert atmosphere

4: hydrogen / 5%-palladium/activated carbon / ethanol / 1 h / 20 °C / 825.08 Torr

With copper(l) iodide; sodium azide; N-Acetylcysteine; hydrogen; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium L-ascorbate; 5%-palladium/activated carbon; In ethanol; dichloromethane; water;

Reference yield:

: 1386985-79-0
2-[2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

: 1386985-84-7
[5-(5-amino-2-fluoro-phenyl)-2,2-bis-fluoromethyl-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia / methanol / 16 h / 50 - 55 °C / Sealed tube

2: trifluoroacetic anhydride; 4-methyl-morpholine / dichloromethane / 0.75 h / 20 °C

3: potassium carbonate; N-Acetylcysteine / ethanol / 16 h / Reflux

4: dichloromethane / 16 h / 20 °C

5: sodium azide; copper(l) iodide; sodium L-ascorbate; trans-N,N'-dimethylcyclohexane-1,2-diamine / ethanol; water / 0.75 h / 70 °C / Inert atmosphere

6: hydrogen / 5%-palladium/activated carbon / ethanol / 1 h / 20 °C / 825.08 Torr

With 4-methyl-morpholine; copper(l) iodide; sodium azide; N-Acetylcysteine; ammonia; hydrogen; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium L-ascorbate; trifluoroacetic anhydride; 5%-palladium/activated carbon; In methanol; ethanol; dichloromethane; water;