(Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one

Base Information

• Chemical Name: (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one
• CAS No.: 1608121-24-9
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 1608121-24-9.mol

Synonyms:(Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one

Chemical Property of (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one

There total 14 articles about (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-methoxyphenyl)furan-2(5H)-one → (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one (1608121-24-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2019.151307

Reference yield: 95.0%

(Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-(ethoxymethoxy)phenyl)furan-2(5H)-one → (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one (1608121-24-9)

Guidance literature:

With Dowex 50X₂-100 resin; In methanol; at 35 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.11.096

Reference yield: 74.0%

(p-hydroxyphenyl)boronic acid (71597-85-8) + (Z)-4-bromo-5-((2,2-dimethylchroman-6-yl)methylene)furan-2(5H)-one → (Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one (1608121-24-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; In water; toluene; at 110 ℃; for 36h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2019.151307

upstream raw materials:

methyl (E)-3-(3-methoxyphenyl)-3-methylacrylate

4-(4-methoxyphenyl)furan-2(5H)-one

4-(4-hydroxyphenyl)furan-2(5H)-one

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde

Downstream raw materials:

(Z)-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one