3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

Base Information

Chemical Name:3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide
CAS No.:245342-71-6
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

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Chemical Property of 3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

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Technology Process of 3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

There total 4 articles about 3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 114094-69-8
3-(1-methylethoxy)-4-methylcyclobut-3-ene-1,2-dione

: 245342-62-5
N-benzyl propargyl 3,3-dimethylacrylamide

: 245342-71-6
3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/jo990089v

Reference yield:

: 61699-62-5
diisopropyl squarate

: 245342-71-6
3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 1.25 h / -20 °C

1.2: 642.8 mg / aq. HCl / CH₂Cl₂ / 1 h

2.1: 87 percent / LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; 1.1: Addition / 1.2: Hydrolysis / 2.1: Addition;
DOI:10.1021/jo990089v

Reference yield:

: 100-39-0
benzyl bromide

: 245342-71-6
3-methylbut-2-enoic acid benzyl[3-(1-hydroxy-2-isopropoxy-3-methyl-4-oxocyclobut-2-enyl)prop-2-ynyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaH / tetrahydrofuran / 20 °C

2: 87 percent / LiHMDS / tetrahydrofuran; hexane / 2 h / -78 °C

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; 1: Alkylation / 2: Addition;
DOI:10.1021/jo990089v