3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

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Chemical Name:3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid
CAS No.:1374961-92-8
Molecular Formula:C₃₄H₂₉ClN₂O₅
Molecular Weight:581.068
Hs Code.:

Synonyms:3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

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Chemical Property of 3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

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Technology Process of 3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

There total 9 articles about 3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1374961-83-7
methyl 3-{N-benzyl-2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

: 1374961-92-8
3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

Guidance literature:: methyl 3-{N-benzyl-2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 1374961-72-4
methyl 5-isopropyl-3-phenylisoxazole-4-carboxylate

: 1374961-92-8
3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

4.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

5.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide / tetrahydrofuran; water / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 1374961-77-9
2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzaldehyde

: 1374961-92-8
3-{N-benzyl-2-chloro-4-{[5-isopropyl-3-phenylisoxazol-4-yl]methoxy}benzamido}benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 12 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydride; methanesulfonyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016