methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

Base Information

Chemical Name:methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate
CAS No.:1374961-88-2
Molecular Formula:C₂₈H₂₅ClN₂O₅
Molecular Weight:504.97
Hs Code.:

Synonyms:methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

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Chemical Property of methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

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Technology Process of methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

There total 6 articles about methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 4518-10-9
Methyl 3-aminobenzoate

: 1374961-80-4
2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzoic acid

: 1374961-88-2
methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 1374961-72-4
methyl 5-isopropyl-3-phenylisoxazole-4-carboxylate

: 1374961-88-2
methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

5: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; carbon tetrabromide; diisobutylaluminium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 100-52-7
benzaldehyde

: 1374961-88-2
methyl 3-{2-chloro-4-[(5-isopropyl-3-phenylisoxazol-4-yl)methoxy]benzamido}benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 90 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

3: sodium methylate; triethylamine / methanol / 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran / 0 °C

5: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

7: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C

8: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; N-chloro-succinimide; 2-methyl-but-2-ene; carbon tetrabromide; hydroxylamine hydrochloride; sodium methylate; diisobutylaluminium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.03.016