(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Base Information

Chemical Name:(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid
CAS No.:1431972-44-9
Molecular Formula:C₂₉H₂₅NO₄
Molecular Weight:451.522
Hs Code.:

Synonyms:(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

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Chemical Property of (R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

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Technology Process of (R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

There total 10 articles about (R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1354812-23-9
(R)-5-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-1-methylpyridin-2(1H)-one

: 14047-29-1
4-carboxyphenylboronic acid

: 1431972-44-9
(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2h;

Reference yield:

: 1354812-21-7
(R)-3-(4-bromophenyl)-1-(6-methoxypyridin-3-yl)-3-o-tolylpropan-1-one

: 1431972-44-9
(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: water; hydrogenchloride / 1,4-dioxane / 1.75 h / 100 °C

2: potassium carbonate / N,N-dimethyl acetamide / 17 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2 h / 80 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water; 3: |Suzuki Coupling;

Reference yield:

: 1354812-22-8
(R)-5-(3-(4-bromophenyl)-3-o-tolylpropanoyl)pyridin-2(1H)-one

: 1431972-44-9
(R)-4'-(3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-3-oxo-1-o-tolylpropyl)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 17 h / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2 h / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water; 2: |Suzuki Coupling;