(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

Base Information

Chemical Name:(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide
CAS No.:1239362-50-5
Molecular Formula:C₁₉H₁₉FN₆O
Molecular Weight:366.398
Hs Code.:

Synonyms:(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

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Chemical Property of (S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

Chemical Property:

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Technology Process of (S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

There total 6 articles about (S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1239362-50-5
(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylphosphoranyl azide; triethylamine / Reflux

2: sodium t-butanolate / palladium diacetate / 1,4-dioxane / 10 h / 100 °C / Inert atmosphere

3: sodium t-butanolate; XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 100 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5: dmap; triethylamine / dichloromethane / 20 °C

With dmap; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; palladium diacetate; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1239363-34-8
(S)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,4,6-triamine

: 108-24-7
acetic anhydride

: 1239362-50-5
(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 501907-61-5
tert-butyl (2,6-dichloropyridin-4-yl)carbamate

: 1239362-50-5
(S)-N-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}aminoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate / 1,4-dioxane / 10 h / 89 °C / Inert atmosphere

2: sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / toluene / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4: triethylamine; dmap / dichloromethane / 20 °C

With dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; In 1,4-dioxane; dichloromethane; toluene;