(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Base Information

Chemical Name:(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate
CAS No.:647840-39-9
Molecular Formula:C₅₆H₈₀N₂O₁₃Si
Molecular Weight:1017.34
Hs Code.:

(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Synonyms:(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Suppliers and Price of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

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Technology Process of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

There total 5 articles about (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 333754-19-1
(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-1,13-dihydroxy-5,20-epoxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-ene

: 647840-38-8
(3R,4S)-1-(tert-butoxycarbonyl)-4-(5-ethyl-2-pyridyl)-3-triisopropylsilyloxy-2-azetidinone

: 647840-39-9
(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; cooling;
DOI:10.1016/S0968-0896(03)00454-1

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 647840-39-9
(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / 20 °C

2: 95 percent / LiHMDS / tetrahydrofuran / cooling

With dmap; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/S0968-0896(03)00454-1

Reference yield:

: 647840-22-0
N-(4-methoxyphenyl)-(5-ethyl-2-pyridyl)methanaldimine

: 647840-39-9
(1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(5-ethyl-2-pyridyl)-2-triisopropylsilyloxypropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: 59 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.17 h / cooling

3.1: 92 percent / 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / 20 °C

4.1: 95 percent / LiHMDS / tetrahydrofuran / cooling

With dmap; ammonium cerium(IV) nitrate; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; hexane; water; acetonitrile;
DOI:10.1016/S0968-0896(03)00454-1