333754-19-1

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 

Downstream Products

• 935670-38-5 C₅₂H₇₁NO₁₃Si 
• 935670-10-3 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3R)-3-(tert-butoxycarbonylamino)-4,4-difluoro-2-hydroxybutyrate 
• 935670-09-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3R)-3-(tert-butoxycarbonylamino)-4,4-difluoro-2-[(triisopropylsilyl)oxy]butyrate 
• 272129-21-2 9-β-dihydro-9,10-O-acetal taxane 
• 512186-54-8 C₄₇H₅₉NO₁₃ 
• 512186-59-3 C₄₆H₅₈N₂O₁₃ 
• 512186-56-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1-hyd roxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-(2-pyridyl)propionate 
• 512186-52-6 C₄₆H₅₇NO₁₃ 
• 647840-51-5 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-1-hydroxy-9,10-[(1S)-2-propenylidenedioxy]tax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-(5-trifluoromethyl-2-pyridyl)propionate 

Relevant academic research and scientific papers

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3.

We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9beta-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.