(S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester

Base Information

• Chemical Name: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester
• CAS No.: 1023700-90-4
• Molecular Formula: C₁₈H₂₅BrClNO₂
• Molecular Weight: 402.759
• Mol file: 1023700-90-4.mol

Synonyms:(S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester

Chemical Property of (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester

There total 1 articles about (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.5%

(S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate (914382-66-4) + 3-chloro4-bromo-benzaldehyde (120077-69-2) → (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester (1023700-90-4)

Guidance literature:

(S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate; 3-chloro4-bromo-benzaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 2.33333h;

With hydrogenchloride; water; In dichloromethane;

Reference yield: 7.4%

(S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester (1023700-90-4) + bis(pinacol)diborane (73183-34-3) → cyclopentyl N-[3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-L-leucinate (1023700-89-1)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 5h;

upstream raw materials:

(S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate

3-chloro4-bromo-benzaldehyde

Downstream raw materials:

cyclopentyl N-[3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-L-leucinate