2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine

Base Information

• Chemical Name: 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine
• CAS No.: 1609012-21-6
• Molecular Formula: C₃₄H₃₇N₇
• Molecular Weight: 543.715
• Mol file: 1609012-21-6.mol

Synonyms:2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine

Chemical Property of 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine

There total 3 articles about 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)-1-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethanol (1494548-16-1) → 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine (1609012-21-6)

Guidance literature:

With diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jm5004182

Reference yield:

3-(bromomethyl)benzaldehyde (82072-23-9) → 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine (1609012-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 0.33 h / -78 °C

2.1: triphenylphosphine; diethylazodicarboxylate; diphenylphosphoranyl azide / tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; 2.1: |Mitsunobu Displacement;

DOI:10.1021/jm5004182

Reference yield:

2-(2,5-dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridine (179554-66-6) → 2-(2-azido-2-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridine (1609012-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 0.33 h / -78 °C

2.1: triphenylphosphine; diethylazodicarboxylate; diphenylphosphoranyl azide / tetrahydrofuran / 1 h / 20 °C

With n-butyllithium; diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; 2.1: |Mitsunobu Displacement;

DOI:10.1021/jm5004182

upstream raw materials:

2-(2,5-dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridine

3-(bromomethyl)benzaldehyde

2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)-1-(3-(2-(6-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methylpyridin-2-yl)ethyl)phenyl)ethanol

Downstream raw materials:

(R)-6-(2-amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine

(S)-6-(2-amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine