82072-23-9

Basic information

• Product Name: 3-(BROMOMETHYL)BENZALDEHYDE
• Synonyms: 3-(Bromomethyl)benzaldehyde 97%;3-Formylbenzyl bromide;3-(BroMoMthyl)Benzaldehyde;3-(Bromomethyl)benzaldehyde97%;3-(BROMOMETHYL)BENZALDEHYDE
• CAS NO: 82072-23-9
• Molecular Formula: C₈H₇BrO
• Molecular Weight: 199.04
• Mol File: 82072-23-9.mol
• Article Data: 29

Chemical Properties

• Melting Point: 49 °C
• Boiling Point: 269.742 °C at 760 mmHg
• Flash Point: 101.268 °C
• Appearance: /
• Density: 1.524 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(BROMOMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(BROMOMETHYL)BENZALDEHYDE(82072-23-9)
• EPA Substance Registry System: 3-(BROMOMETHYL)BENZALDEHYDE(82072-23-9)

Safety Data

• Hazard Codes: C
• Statements: 20/22-34
• Safety Statements: 22-26-36/37/39-45
• Hazardous Substances Data: 82072-23-9(Hazardous Substances Data)

Usage

General Description

3-(Bromomethyl)benzaldehyde is a chemical compound that is used as a starting material or intermediate in organic synthesis. This aromatic aldehyde is characterized by the presence of a bromomethyl group (-CH2Br) and an aldehyde group (-CHO) on the benzene ring. The bromine atom in the bromomethyl group makes it a good leaving group, allowing it to be substituted with other groups in various chemical reactions. 3-(Bromomethyl)benzaldehyde is typically produced through the bromination of tolualdehyde. Its applications include the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has a molecular formula of C8H7BrO and is also known under the CAS number 620-15-7.

InChI:InChI=1/C8H7BrO/c9-5-7-2-1-3-8(4-7)6-10/h1-4,6H,5H2

Upstream product

• 28188-41-2 m-(bromomethyl)benzonitrile 
• 1191-15-7 diisobutylaluminium hydride 
• 626-18-6 1,3-dimethanol benzene 
• 7647-01-0 hydrogenchloride 
• 620-23-5 m-tolyl aldehyde 
• 82072-22-8 3-hydroxymethylbenzyl bromide 
• 626-19-7 Isophthalaldehyde 
• 52010-98-7 3-(hydroxymethyl)benzaldehyde 

Downstream Products

• 133671-91-7 5,10,15,20-tetrakis(α-bromo-m-tolyl)porphyrin 
• 139408-01-8 5,10,15-Tris(α-bromo-m-tolyl)-20-m-tolylporphyrin 
• 110360-69-5 α-(N'-5-Fluorouracilo)-m-tolualdehyde 
• 138117-10-9 1,8-bis(3-formylbenzoxy)-9,10-anthraquinone 
• 156866-51-2 3-(S-acetylthiomethyl)benzaldehyde 
• 185908-93-4 3-(3-formylphenoxy)benzoic acid methyl ester 
• 78425-11-3 C₁₁H₁₀N₂O 
• 1204300-29-7 3-(3,5-dimethylpyrazol-1-ylmethyl)benzaldehyde 
• 911431-50-0 3-[(diethylamino)methyl]-benzaldehyde 
• 1308662-08-9 2-{3-[((S)-1-dimethylaminomethyl-2-phenyl-ethylamino)-methyl]-benzyl}-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester 
• 1308662-42-1 2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1 dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid 
• 1308662-41-0 2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester 
• 1308662-17-0 2-(3-{[(6-Chloro-2-fluoro-3-methoxy-benzyl)-((S)-1-dimethylaminomethyl-3,3-dimethyl-butyl)-amino]-methyl}-benzyl)-1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester 
• 1351815-61-6 cyclopentyl N-{3-[(methylamino)methyl]benzyl}-L-leucinate 

Relevant articles and documents

Synthesis and evaluation of novel α-aminoamides containing benzoheterocyclic moiety for the treatment of pain

Novel α-aminoamide derivatives containing different benzoheterocyclics moiety were synthesized and evaluated as voltage-gated sodium ion channels blocks the treatment of pain. Compounds 6a, 6e, and 6f containing the benzofuran group displayed more potent in vivo analgesic activity than ralfinamide in both the formalin test and the writhing assay. Interestingly, they also exhibited potent in vitro anti-Nav 1.7 and anti-Nav 1.8 activity in the patch-clamp electrophysiology assay. Therefore, compounds 6a, 6e, and 6f, which have inhibitory potency for two pain-related Nav targets, could serve as new leads for the development of analgesic medicines.

Amide derivative containing benzoheterocycle structure, and composition and application thereof

The invention belongs to the technical field of medicines, and discloses an amide derivative containing a benzoheterocycle structure, and a composition and an application thereof. The amide derivativecontaining the benzoheterocycle structure is a compound represented by structural formula I and a nontoxic pharmaceutically acceptable salt thereof, or the amide derivative containing the benzoheterocycle structure is a compound represented by structural formula II or a nontoxic pharmaceutically acceptable salt thereof. The amide derivative containing the benzoheterocycle structure has good analgesic activity and good inhibition effect on a target sodium ion channel Nav1.7.

Design, Synthesis, and Biological Evaluation of Novel Acylhydrazone Derivatives as Potent Neuraminidase Inhibitors

Neuraminidase (NA) is an important target for current research on anti-influenza drugs. The acylhydrazone derivatives containing the -CONHN═CH- framework have been shown to have good NA inhibitory activity. In this paper, a series of novel acylhydrazone NA inhibitors (9a-9n) were designed and synthesized, and the inhibitory activities against NA were evaluated in vitro. The NA inhibition results showed that compound 9j has the most potent inhibitory activity (IC50 = 0.6 μM) against NA, which is significantly lower than that of the positive control oseltamivir carboxylic acid (OSC) (IC50 = 17.00 μM). Molecular docking analysis indicates that the acylhydrazone group plays an important role in compound 9j, which can bind well to the residues Arg371 and Arg292 in the S1 subsite of NA. The good potency of 9j may be also ascribed to the extending of morpholinyl ring into the 430-cavity. The results of this work may contribute to the development of more potent NA inhibitors to against mutant influenza viruses.