82072-23-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(Bromomethyl)benzaldehyde is used as a starting material or intermediate for the synthesis of various pharmaceuticals. Its reactivity and the presence of a good leaving group make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
3-(Bromomethyl)benzaldehyde is used as a starting material or intermediate in the synthesis of agrochemicals. Its versatility in chemical reactions allows for the creation of compounds with potential applications in agriculture, such as pesticides and herbicides.
Used in Organic Synthesis:
3-(Bromomethyl)benzaldehyde is used as a building block in the synthesis of other organic compounds. Its reactivity and the ability to substitute the bromomethyl group with other functional groups make it a useful component in the creation of a wide range of chemical products.

InChI:InChI=1/C8H7BrO/c9-5-7-2-1-3-8(4-7)6-10/h1-4,6H,5H2

Upstream product

• 82072-22-8 3-hydroxymethylbenzyl bromide 
• 620-23-5 m-tolyl aldehyde 
• 626-18-6 1,3-dimethanol benzene 
• 7647-01-0 hydrogenchloride 
• 28188-41-2 m-(bromomethyl)benzonitrile 
• 1191-15-7 diisobutylaluminium hydride 
• 626-19-7 Isophthalaldehyde 
• 52010-98-7 3-(hydroxymethyl)benzaldehyde 

Downstream Products

• 133671-91-7 5,10,15,20-tetrakis(α-bromo-m-tolyl)porphyrin 
• 139408-01-8 5,10,15-Tris(α-bromo-m-tolyl)-20-m-tolylporphyrin 
• 138829-02-4 3,3′-(thiobis(methylene))dibenzaldehyde 
• 138117-08-5 2,2-bis<4-(3-formylbenzyloxy)phenyl>propane 
• 191276-44-5 Terephthalic acid bis-(3-formyl-benzyl) ester 
• 191276-45-6 [4-(3-Formyl-benzyloxycarbonylmethyl)-phenyl]-acetic acid 3-formyl-benzyl ester 
• 152424-56-1 (1,1-dimethyl-3,5-dioxacyclohex-4-yl)-3-bromomethylbenzene 
• 198978-88-0 3-nitrooxymethyl-benzaldehyde 
• 66768-46-5 all-cis<2₄>metacyclophanetetraene 
• 66726-63-4 cis,cis,cis,trans<2₄>metacyclophanetetraene 
• 89822-57-1 all-cis[2₃]metacyclophanetriene 
• 849016-06-4 dimethyl (3-formylbenzyl)phosphonate 
• 185908-93-4 3-(3-formylphenoxy)benzoic acid methyl ester 
• 1096158-95-0 C₁₈H₂₁N₅O₃ 

Relevant academic research and scientific papers

Synthesis and evaluation of novel α-aminoamides containing benzoheterocyclic moiety for the treatment of pain

Novel α-aminoamide derivatives containing different benzoheterocyclics moiety were synthesized and evaluated as voltage-gated sodium ion channels blocks the treatment of pain. Compounds 6a, 6e, and 6f containing the benzofuran group displayed more potent in vivo analgesic activity than ralfinamide in both the formalin test and the writhing assay. Interestingly, they also exhibited potent in vitro anti-Nav 1.7 and anti-Nav 1.8 activity in the patch-clamp electrophysiology assay. Therefore, compounds 6a, 6e, and 6f, which have inhibitory potency for two pain-related Nav targets, could serve as new leads for the development of analgesic medicines.

Galantamine-curcumin hybrids as dual-site binding acetylcholinesterase inhibitors

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer's disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. The designed hybrids are screened for optimal ADME properties and BBB permeability and docked on AChE. The 14 best performing compounds are synthesized and tested in vitro for neurotoxicity and anti-AChE activity. Five of them are less toxic than GAL and CU and show activities between 41 and 186 times higher than GAL.

Amide derivative containing benzoheterocycle structure, and composition and application thereof

The invention belongs to the technical field of medicines, and discloses an amide derivative containing a benzoheterocycle structure, and a composition and an application thereof. The amide derivativecontaining the benzoheterocycle structure is a compound represented by structural formula I and a nontoxic pharmaceutically acceptable salt thereof, or the amide derivative containing the benzoheterocycle structure is a compound represented by structural formula II or a nontoxic pharmaceutically acceptable salt thereof. The amide derivative containing the benzoheterocycle structure has good analgesic activity and good inhibition effect on a target sodium ion channel Nav1.7.

Acylhydrazone neuraminidase inhibitor as well as preparation method and application thereof

The invention relates to an acylhydrazone neuraminidase inhibitor as well as a preparation method and application thereof, and the acylhydrazone neuraminidase inhibitor has a structure as shown in a general formula L. The disclosed compound is novel in structure, and experiments show that the acylhydrazone neuraminidase inhibitor has good neuraminidase inhibition activity and is expected to be used for preparing medicines for inhibiting neuraminidase activity.

Design, Synthesis, and Biological Evaluation of Novel Acylhydrazone Derivatives as Potent Neuraminidase Inhibitors

Neuraminidase (NA) is an important target for current research on anti-influenza drugs. The acylhydrazone derivatives containing the -CONHN═CH- framework have been shown to have good NA inhibitory activity. In this paper, a series of novel acylhydrazone NA inhibitors (9a-9n) were designed and synthesized, and the inhibitory activities against NA were evaluated in vitro. The NA inhibition results showed that compound 9j has the most potent inhibitory activity (IC50 = 0.6 μM) against NA, which is significantly lower than that of the positive control oseltamivir carboxylic acid (OSC) (IC50 = 17.00 μM). Molecular docking analysis indicates that the acylhydrazone group plays an important role in compound 9j, which can bind well to the residues Arg371 and Arg292 in the S1 subsite of NA. The good potency of 9j may be also ascribed to the extending of morpholinyl ring into the 430-cavity. The results of this work may contribute to the development of more potent NA inhibitors to against mutant influenza viruses.

Synthesis of various cyclopropyl methyl bromide and its derivatives from ketones and/or aldehydes and some β-dicarbonyl compounds in the presence of BrCN and Et3N

The ultimate goal in this paper has been developed for the synthesis of structurally various bromomethyl cyclopropane via an α-bromoketone and/or aldehydes with ethyl cyanoacetate or malononitrile and cyanogen bromide (BrCN) in the presence of Et3N to give products in excellent yields within about 3?s. All structures were characterized by IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. The reaction mechanism was discussed.

Pharmaceutical composition for use in preventing or treating poly(ADP-ribose)polymerase-1 related diseases containing the same as an active ingredient

The present invention relates to a novel compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating poly(ADP-ribose)polymerase-1 (PARP-1) related diseases containing the compound as an active ingredient. The novel PARP-1 inhibitory compound according to the present invention exhibits an excellent PARP-1 inhibitory effect at a concentration of nanomol unit and further exhibits an excellent cytoprotective effect (cell death inhibitory effect) on ophthalmic diseases or disorders, especially on retinal diseases. The composition containing the compound as an active ingredient is useful as a composition for preventing or treating PARP-1 related diseases, for example, ophthalmic diseases or disorders.(AA) Example 37(BB) Example 39COPYRIGHT KIPO 2018

Indole group-containing alpha-amino amide derivatives and pharmaceutical application thereof

The invention relates to new indole group-containing alpha-amino amide derivatives represented by the structural formula I or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the compounds as active ingredients, and an application of the derivatives or the pharmaceutically acceptable salts thereof in preparation of analgesic drugs. In the structural formula I, R is a hydrogen atom or C1-C5 straight-chain alkyl or branched-chain alkyl, and the configuration of carbon atoms connected to R is an R type or an S type.

Novel alpha-amino amide derivatives and pharmaceutical use thereof

The invention relates to novel alpha-amino amide derivatives and a pharmaceutical use thereof. Specifically, the invention relates to the alpha-amino amide derivatives represented by the structural formula I or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the compounds as active ingredients, and the use of the derivatives or the pharmaceutically acceptable salts thereof for preparation of analgesic drugs.

SMALL MOLECULE INHIBITORS OF ALDH AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.