4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate

Base Information

• Chemical Name: 4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate
• CAS No.: 1416227-66-1
• Molecular Formula: C₄H₆O₆*C₂₂H₂₇ClN₂
• Molecular Weight: 512.947

Synonyms:4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate

Chemical Property of 4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate

Chemical Property:

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Technology Process of 4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate

There total 26 articles about 4-((1R,3S)-6-chloro-3-(phenyl-d₅)-indan-1-yl)-1(d₃),2,2-trimethylpiperazine L-(+)-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

L-Tartaric acid (87-69-4,138508-61-9) + 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine → 4-((1R,3S)-6-chloro-3-(phenyl-d5)-indan-1-yl)-1(d3),2,2-trimethylpiperazine L-(+)-tartrate (1416227-66-1)

Guidance literature:

In ethanol; acetone; Inert atmosphere; Reflux;

Reference yield: 37.0%

L-Tartaric acid (87-69-4,138508-61-9) + C4H6O4*C22H19(2)H8ClN2 (1416227-19-4) → 4-((1R,3S)-6-chloro-3-(phenyl-d5)-indan-1-yl)-1(d3),2,2-trimethylpiperazine L-(+)-tartrate (1416227-66-1)

Guidance literature:

C₄H₆O₄*C₂₂H₁₉⁽²⁾H₈ClN₂; With ammonia; In water; ethyl acetate;

L-Tartaric acid; In acetone; Reflux; Industry scale;

Reference yield:

bromobenzene-d5 (4165-57-5) → 4-((1R,3S)-6-chloro-3-(phenyl-d5)-indan-1-yl)-1(d3),2,2-trimethylpiperazine L-(+)-tartrate (1416227-66-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: magnesium; sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1.5 h / Inert atmosphere; Reflux

1.2: 1.5 h / 50 °C / Inert atmosphere

2.1: tetrahydrofuran / 2.5 h / 20 - 45 °C / Inert atmosphere

3.1: sodium periodate / tetrahydrofuran; water / 1.5 h / 60 °C / Inert atmosphere

4.1: hydrogen; palladium(II) trifluoroacetate; (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine / dichloromethane / 20 °C / 3000.3 Torr

5.1: sodium tetrahydroborate / tetrahydrofuran; isopropyl alcohol / -10 - 20 °C / Inert atmosphere

6.1: thionyl chloride / tetrahydrofuran / 90 h / 10 - 15 °C / Inert atmosphere

7.1: potassium carbonate / 35 h / 90 - 95 °C / Inert atmosphere

8.1: 75 - 80 °C / Inert atmosphere

9.1: ammonium hydroxide / water; tert-butyl methyl ether / Inert atmosphere

9.2: 20 - 25 °C / Inert atmosphere

10.1: acetone / Reflux; Inert atmosphere

11.1: ammonium hydroxide; water / ethyl acetate / Inert atmosphere

11.2: Reflux; Inert atmosphere; Resolution of racemate

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; ammonium hydroxide; sodium tetrahydroborate; sodium periodate; thionyl chloride; palladium(II) trifluoroacetate; water; hydrogen; potassium carbonate; magnesium; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol; acetone; toluene;

upstream raw materials:

L-Tartaric acid

C₄H₆O₄*C₂₂H₁₉⁽²⁾H₈ClN₂

bromobenzene-d5

5-chloro-1-indanone

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