N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

Base Information

Chemical Name:N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide
CAS No.:1334672-22-8
Molecular Formula:C₂₅H₂₉N₃O₂
Molecular Weight:403.524
Hs Code.:

Synonyms:N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

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Chemical Property of N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

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Technology Process of N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

There total 4 articles about N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 956242-70-9
C₂₄H₂₇N₃O₂

: 74-88-4
methyl iodide

: 1334672-22-8
N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

Guidance literature:: C₂₄H₂₇N₃O₂; With sodium hydride; In acetonitrile; for 1.5h; Cooling with ice; Inert atmosphere;

methyl iodide; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ardp.201000296

Reference yield:

: 956243-28-0
C₁₉H₁₉N₃O

: 1334672-22-8
N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine / chloroform / Reflux

2.1: sodium hydride / acetonitrile / 1.5 h / Cooling with ice; Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In chloroform; acetonitrile;
DOI:10.1002/ardp.201000296

Reference yield:

: 956242-65-2
C₂₄H₂₇N₃O₃

: 1334672-22-8
N-[(2'-cyanobiphenyl-4-yl)methyl]-N-methyl-1-pentanoylpyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / ethyl acetate / 20 °C

2.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine / chloroform / Reflux

3.1: sodium hydride / acetonitrile / 1.5 h / Cooling with ice; Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

With hydrogen bromide; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In chloroform; ethyl acetate; acetonitrile;
DOI:10.1002/ardp.201000296