C₁₈H₃₁NO₂Si

Base Information

• Chemical Name: C₁₈H₃₁NO₂Si
• CAS No.: 1186197-53-4
• Molecular Formula: C₁₈H₃₁NO₂Si
• Molecular Weight: 321.535
• Mol file: 1186197-53-4.mol

Synonyms:C₁₈H₃₁NO₂Si

Chemical Property of C₁₈H₃₁NO₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₈H₃₁NO₂Si

There total 3 articles about C₁₈H₃₁NO₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-[(tert-butoxycarbonyl)(methyl)amino]-2-[4-(tert-butyldimethylsiloxy)but-1-en-2-yl]-4-methoxybenzene (1186197-51-2) → C18H31NO2Si (1186197-53-4)

Guidance literature:

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/b907210a

Reference yield:

tert-butyl (2-iodo-4-methoxyphenyl)carbamate (157496-75-8) → C18H31NO2Si (1186197-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

2.3: 16 h / Reflux; Inert atmosphere

3.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/b907210a

Reference yield:

(2-iodo-4-methoxy-phenyl)-methyl-carbamic acid tert-butyl ester → C18H31NO2Si (1186197-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.25 h / 0 °C / Inert atmosphere

1.3: 16 h / Reflux; Inert atmosphere

2.1: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1039/b907210a

upstream raw materials:

1-[(tert-butoxycarbonyl)(methyl)amino]-2-[4-(tert-butyldimethylsiloxy)but-1-en-2-yl]-4-methoxybenzene

tert-butyl (2-iodo-4-methoxyphenyl)carbamate

Downstream raw materials:

C₂₀H₃₀N₂O₃Si