methyl cyclopentyl(3-methoxyphenethyl)carbamate

Base Information

• Chemical Name: methyl cyclopentyl(3-methoxyphenethyl)carbamate
• CAS No.: 1260224-81-4
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.364
• Mol file: 1260224-81-4.mol

Synonyms:methyl cyclopentyl(3-methoxyphenethyl)carbamate

Chemical Property of methyl cyclopentyl(3-methoxyphenethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl cyclopentyl(3-methoxyphenethyl)carbamate

There total 2 articles about methyl cyclopentyl(3-methoxyphenethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-[2-(3-methoxyphenyl)ethyl]cyclopentylamine (1158694-62-2) + methyl chloroformate (79-22-1) → methyl cyclopentyl(3-methoxyphenethyl)carbamate (1260224-81-4)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm1012165

Reference yield:

2-(3-methoxyphenyl)-1-ethanamine (2039-67-0) → methyl cyclopentyl(3-methoxyphenethyl)carbamate (1260224-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 0.17 h / 110 °C / Microwave irradiation; Inert atmosphere

2: triethylamine / diethyl ether / 0 - 20 °C / Inert atmosphere

With triethylamine; In diethyl ether; acetonitrile;

DOI:10.1021/jm1012165

Reference yield:

methyl cyclopentyl(3-methoxyphenethyl)carbamate (1260224-81-4) → methyl 4-chloro-3'-((2-cyclopentyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yloxy)methyl)biphenyl-3-carboxylate (1260224-84-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: phosphorus pentoxide; trichlorophosphate / 2 h / 100 °C / Inert atmosphere

2.1: boron tribromide / benzene / 0 - 80 °C

2.2: 1 h / 100 °C

3.1: potassium carbonate / acetonitrile / 12 h / 80 °C / Inert atmosphere

With phosphorus pentoxide; boron tribromide; potassium carbonate; trichlorophosphate; In acetonitrile; benzene; 1.1: Bischler-Napieralski cyclization;

DOI:10.1021/jm1012165

upstream raw materials:

N-[2-(3-methoxyphenyl)ethyl]cyclopentylamine

methyl chloroformate

2-(3-methoxyphenyl)-1-ethanamine

Downstream raw materials:

methyl 4-chloro-3'-((2-cyclopentyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yloxy)methyl)biphenyl-3-carboxylate

4-chloro-3'-((2-cyclopentyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yloxy)methyl)biphenyl-3-carboxylic acid