1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone
CAS No.:1575819-73-6
Molecular Formula:C₂₀H₂₉F₃N₄O₃
Molecular Weight:430.47
Hs Code.:

Synonyms:1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

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Chemical Property of 1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

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Technology Process of 1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

There total 4 articles about 1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575819-73-6
1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: dichloromethane / 1.5 h / 0 - 20 °C

3: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1575819-57-6
tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

: 1575819-73-6
1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1.5 h / 0 - 20 °C

2: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

3: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1575819-71-4
3-nitro-4-(pyrrolidin-2-ylmethylamino)benzaldehyde trifluoroacetate

: 1575819-73-6
1-(2-((4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenylamino)methyl)pyrrolidin-1-yl)-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane;