(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

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Chemical Name:(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester
CAS No.:221110-60-7
Molecular Formula:C₄₃H₆₀N₆O₁₀
Molecular Weight:820.984
Hs Code.:

(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

Synonyms:(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

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Chemical Property of (S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

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Technology Process of (S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

There total 6 articles about (S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 151275-35-3
(S)-1-[(S)-3-Methoxycarbonyl-2-(2-propyl-pentanoylamino)-propionyl]-pyrrolidine-2-carboxylic acid

: 3-[3-piperidyl-(N-guanidino(bis-benzyloxycarbonyl))]-L-alaninol, hydrochloride salt

: 221110-60-7
(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile;
DOI:10.1021/jm960607j

Reference yield:

: 167298-45-5
(S)-[1-(hydroxymethyl)-2-(3-pyridinyl)ethyl]carbamic acid 1,1-dimethylethyl ester

: 221110-60-7
(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent PtO₂ / methanol / 2068.6 Torr

2: 82 percent / NMM / tetrahydrofuran

3: 100 percent / HCl / methanol

4: 81 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm960607j

Reference yield:

: 117142-26-4,105454-25-9
(S)-2-tert-butoxycarbonylamino-3-pyridin-3-yl-propionic acid

: 221110-60-7
(S)-4-{(S)-2-[(S)-2-(1-{Benzyloxycarbonylamino-[(E)-benzyloxycarbonylimino]-methyl}-piperidin-3-yl)-1-hydroxymethyl-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / BH₃ / tetrahydrofuran

2: 100 percent / H₂ / 10percent PtO₂ / methanol / 2068.6 Torr

3: 82 percent / NMM / tetrahydrofuran

4: 100 percent / HCl / methanol

5: 81 percent / EDC, HOBt, NMM / acetonitrile

With 4-methyl-morpholine; hydrogenchloride; borane; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm960607j