N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

Base Information

Chemical Name:N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide
CAS No.:1616475-49-0
Molecular Formula:C₂₇H₃₁N₅O₂
Molecular Weight:457.575
Hs Code.:

Synonyms:N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

Chemical Property:

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Technology Process of N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

There total 8 articles about N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₃N₅O₂S

: 1616475-49-0
N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In acetonitrile; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

: 1616475-39-8
N¹-(5-(3-(dimethylamino)propoxy)-2-nitrophenyl)-N³,N³-dimethylbenzene-1,3-diamine

: 1616475-49-0
N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 20 °C / 760.05 Torr / Inert atmosphere

2: acetonitrile / 3 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / acetonitrile / 21 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

: 5407-04-5
3-(dimethylamino)propyl chloride hydrochloride

: 1616475-49-0
N-(1-(3-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 41 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 22 h / 20 °C / 760.05 Torr / Inert atmosphere

4: acetonitrile / 3 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide / acetonitrile / 21 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2014.05.009