N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

Base Information

Chemical Name:N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate
CAS No.:1427549-75-4
Molecular Formula:C₃₁H₃₂FN₅O₃
Molecular Weight:541.625
Hs Code.:

Synonyms:N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

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Chemical Property of N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

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Technology Process of N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

There total 8 articles about N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427549-89-0
3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-carboxylic acid

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1427549-75-4
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 2h;

Reference yield:

: 1427549-83-4
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1H-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-75-4
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1427549-87-8
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-75-4
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazol-6-yl]carbonyl}-L-tryptophanate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;