tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate
CAS No.:1362689-46-0
Molecular Formula:C₂₅H₂₃FN₄O₃
Molecular Weight:446.481
Hs Code.:

Synonyms:tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Suppliers and Price of tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

There total 6 articles about tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1362689-45-9
(1-chloroisoquinolin-3-yl)(4-fluorophenyl)methanone

: 578008-32-9
tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate

: 1362689-46-0
tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: With CsCO₃; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; at 70 - 100 ℃; for 4h;

Reference yield:

: 610-97-9
o-iodo-methyl-benzoic acid

: 1362689-46-0
tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 15 h / 55 °C

2.1: hydrogenchloride / water / 3 h / 100 °C

2.2: 20 °C / pH 7

3.1: trichlorophosphate / 2 h / Reflux

3.2: 20 °C / pH 7 / Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 2.5 h / -30 °C

5.1: CsCO₃ / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 4 h / 70 - 100 °C

With hydrogenchloride; CsCO₃; sodium hydrogencarbonate; trichlorophosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tetrabutyl-ammonium chloride; palladium diacetate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1362689-46-0
tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 0 - 20 °C

2: CsCO₃ / 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 4 h / 70 - 100 °C

With CsCO₃; sodium hydride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; In N,N-dimethyl-formamide; mineral oil;