(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

Base Information

Chemical Name:(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate
CAS No.:1559057-66-7
Molecular Formula:C₃₉H₄₂F₂O₇
Molecular Weight:660.755
Hs Code.:

Synonyms:(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

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Chemical Property of (1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

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Technology Process of (1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

There total 4 articles about (1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1559057-52-1
(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3-oxo-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

: 1559057-66-7
(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

Guidance literature:: With DeoxoFluor; In tetrahydrofuran; ethanol; at 0 - 45 ℃; for 36h;

Reference yield:

: 1559057-77-0,130209-78-8
C₂₅H₃₆O₆

: 1559057-66-7
(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane / 11 h / 25 - 40 °C

2: pyridine / dichloromethane / 4 h / 0 - 25 °C

3: DeoxoFluor / tetrahydrofuran; ethanol / 36 h / 0 - 45 °C

With pyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1559057-74-7
(Z)-isopropyl 7-((1R,5S,6R,7R)-7-((E)-3-hydroxy-4-phenoxybut-1-en-1-yl)-3-phenyl-2,4-dioxa-3-borabicyclo[3.2.1]octan-6-yl)hept-5-enoate

: 1559057-66-7
(1S,2R,3R,4R)-4-(benzoyloxy)-3-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-2-[(2Z)-7-oxo-7-(propan-2-yloxy)hept-2-en-1-yl]cyclopentyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: PCC on alumina / dichloromethane / 3 h / 25 °C

2: pyridine / dichloromethane / 4 h / 0 - 25 °C

3: DeoxoFluor / tetrahydrofuran; ethanol / 36 h / 0 - 45 °C

With pyridine; PCC on alumina; In tetrahydrofuran; ethanol; dichloromethane;