N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

Base Information

Chemical Name:N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide
CAS No.:1316808-29-3
Molecular Formula:C₂₅H₃₃N₃O₃S
Molecular Weight:455.621
Hs Code.:

Synonyms:N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

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Technology Process of N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

There total 6 articles about N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1316807-88-1
(4-((3'-aminobiphenyl-4-yl)methyl)piperazin-1-yl)(cyclohexyl)methanone

: 124-63-0
methanesulfonyl chloride

: 1316808-29-3
N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

Guidance literature:: With polystyrene N-methylmorpholine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2011.05.025

Reference yield:

: 936694-19-8
tert-butyl 4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine-1-carboxylate

: 1316808-29-3
N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 0.17 h / 150 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 20 °C

3: polystyrene N-methylmorpholine / dichloromethane / 16 h / 20 °C

4: hydrogen / ethanol; ethyl acetate / 65 °C

5: polystyrene N-methylmorpholine / dichloromethane / 1 h / 20 °C

With tetrabutylammomium bromide; hydrogen; palladium diacetate; potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; water; ethyl acetate; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.05.025

Reference yield:

: 1316807-37-0
tert-butyl 4-((3'-nitrobiphenyl-4-yl)methyl)piperazine-1-carboxylate

: 1316808-29-3
N-(4'-((4-(cyclohexanecarbonyl)piperazin-1-yl)methyl)biphenyl-3-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: polystyrene N-methylmorpholine / dichloromethane / 16 h / 20 °C

3: hydrogen / ethanol; ethyl acetate / 65 °C

4: polystyrene N-methylmorpholine / dichloromethane / 1 h / 20 °C

With hydrogen; trifluoroacetic acid; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tetlet.2011.05.025