1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

Base Information

Chemical Name:1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol
CAS No.:1312505-44-4
Molecular Formula:C₂₀H₁₇F₆N₅OS
Molecular Weight:489.444
Hs Code.:

Synonyms:1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

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Chemical Property of 1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

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Technology Process of 1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

There total 5 articles about 1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1312534-98-7
1-(5-bromo-1,3-thiazol-2-yl)cyclobutanol

: 1312537-06-6
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)-N-4-[(trifluoromethyl)pyrimidin-2-yl]benzene-1,3-diamine

: 1312505-44-4
1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 85 ℃; for 2h;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1312505-44-4
1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride / iron / ethanol; water / 1 h / 80 °C

2.1: sodium cyanoborohydride; trifluoroacetic acid / dichloromethane / 0 °C

2.2: 0.75 h / 20 °C

3.1: hydrogenchloride / water; dimethyl sulfoxide / 2 h / 100 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 85 °C

4.2: 0.5 h / 110 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 85 °C

With hydrogenchloride; potassium acetate; sodium cyanoborohydride; sodium carbonate; ammonium chloride; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; 5.1: Suzuki Coupling;

Reference yield:

: 33786-90-2
5‐bromobenzene‐1,3‐diamine

: 1312505-44-4
1-[5-(3-[(2,2,2-trifiuoroethyl)amino]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride; trifluoroacetic acid / dichloromethane / 0 °C

1.2: 0.75 h / 20 °C

2.1: hydrogenchloride / water; dimethyl sulfoxide / 2 h / 100 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 85 °C

3.2: 0.5 h / 110 °C

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 85 °C

With hydrogenchloride; potassium acetate; sodium cyanoborohydride; sodium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; 4.1: Suzuki Coupling;