(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane
CAS No.:173097-67-1
Molecular Formula:C₂₀H₂₃ClO₃
Molecular Weight:346.854
Hs Code.:

Synonyms:(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Suppliers and Price of (4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

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Technology Process of (4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

There total 6 articles about (4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 173097-66-0
((4S,5S)-5-Chloromethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-diphenyl-methanol

: 74-88-4
methyl iodide

: 173097-67-1
(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: With sodium hydride; In tetrahydrofuran; paraffin;
DOI:10.1002/hlca.19950780703

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 173097-67-1
(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 2.) THF, 1 h, 20-30 deg C

2: 93 percent / Na₂CO₃ / dimethylformamide / 48 h / Ambient temperature

3: 93 percent / NaBH₄ / methanol

4: 79 percent / PPh₃, CCl₄ / 50 °C

5: 97 percent / NaH / tetrahydrofuran; paraffin

With tetrachloromethane; sodium tetrahydroborate; sodium hydride; sodium carbonate; magnesium; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; paraffin;
DOI:10.1002/hlca.19950780703

Reference yield:

: 67844-12-6
methyl (4S,5S)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid-5-carboxylate

: 173097-67-1
(4S,5S)-4-(chloromethyl)-5-(methoxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg / 2.) THF, 1 h, 20-30 deg C

2: 93 percent / Na₂CO₃ / dimethylformamide / 48 h / Ambient temperature

3: 93 percent / NaBH₄ / methanol

4: 79 percent / PPh₃, CCl₄ / 50 °C

5: 97 percent / NaH / tetrahydrofuran; paraffin

With tetrachloromethane; sodium tetrahydroborate; sodium hydride; sodium carbonate; magnesium; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; paraffin;
DOI:10.1002/hlca.19950780703