2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

Base Information

Chemical Name:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester
CAS No.:247575-80-0
Molecular Formula:C₅₀H₆₁N₃O₄
Molecular Weight:768.052
Hs Code.:

2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

Synonyms:2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

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Chemical Property of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

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Technology Process of 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

There total 1 articles about 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 111060-66-3
L-dibenzylvalinal

: 247575-73-1
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester

: 247575-79-7
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-phenyl-ethyl)-2-hydroxy-4-methyl-pentyl ester

: 247575-80-0
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

Guidance literature:: 2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (S)-2-dibenzylamino-3-phenyl-propyl ester; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 ℃; for 6h;

L-dibenzylvalinal; In diethyl ether; hexane; cyclohexane; at -78 - 20 ℃; for 12h;
DOI:10.1055/s-1999-3576

Reference yield:

: 247575-80-0
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

: (1-Methoxy-1-methyl-ethyl)-carbamic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

Guidance literature:: With methanesulfonic acid; In methanol; for 12h; Heating;
DOI:10.1055/s-1999-3576

Reference yield:

: 247575-80-0
2,2,4,4-Tetramethyl-oxazolidine-3-carboxylic acid (1S,2S,3S)-3-dibenzylamino-1-((S)-1-dibenzylamino-2-methyl-propyl)-2-hydroxy-4-phenyl-butyl ester

: [4S,4S(1S),5S(1S)]-5-[1-(N,N-Dibenzylamino)-2-methylpropyl]-4-[1-(N,N-dibenzylamino)-2-phenylethyl]-1,3-dioxolan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: MeSO₃H / methanol / 12 h / Heating

2: K₂CO₃ / methanol / 4 h / Heating

3: 83 percent / K₂CO₃ / 80 °C

With methanesulfonic acid; potassium carbonate; In methanol; 1: Ring cleavage / 2: Hydrolysis / 3: Cyclization;
DOI:10.1055/s-1999-3576