1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine

Base Information

• Chemical Name: 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine
• CAS No.: 859140-20-8
• Molecular Formula: C₃₀H₂₅ClN₄O₅S₂
• Molecular Weight: 621.137
• Mol file: 859140-20-8.mol

Synonyms:1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine

Chemical Property of 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine

There total 5 articles about 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-pyridinyl)benzoic acid (4385-76-6) → 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine (859140-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 89 percent / 1-hydroxybenzotriazole; N-methylmorpholine; 1-(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 7 h / 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 °C

2.2: ethyldiisopropylamine / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.04.006

Reference yield:

6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride (249292-39-5) + 1-(tert-butoxycarbonyl)-4-[4-(4-pyridyl)benzoyl]piperazine (222986-36-9) → 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine (859140-20-8)

Guidance literature:

1-(tert-butoxycarbonyl)-4-[4-(4-pyridyl)benzoyl]piperazine; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2005.04.006

Reference yield:

6-chloro-1-(phenylsulfonyl)indole (231295-53-7) → 1-[(6-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine (859140-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert-butyl lithium / diethyl ether; pentane / -78 - -40 °C

1.2: SO₂ / diethyl ether; pentane / -78 - -40 °C

1.3: 79 percent / N-chlorosuccinimide / CH₂Cl₂ / 8 h / 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 °C

2.2: ethyldiisopropylamine / CH₂Cl₂ / 2 h / 20 °C

With tert.-butyl lithium; trifluoroacetic acid; In diethyl ether; dichloromethane; pentane;

DOI:10.1016/j.bmc.2005.04.006

upstream raw materials:

6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride

1-(tert-butoxycarbonyl)-4-[4-(4-pyridyl)benzoyl]piperazine

6-chloro-1-(phenylsulfonyl)indole

6-chloroindole

Downstream raw materials:

1-[(6-chloroindol-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine