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4385-76-6

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4385-76-6 Usage

General Description

4-Pyrid-4-ylbenzoic acid is a chemical compound with the molecular formula C12H9NO2. It is a derivative of benzoic acid with a pyridine ring attached to the para position of the benzene ring. 4-Pyrid-4-ylbenzoic acid is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs. It is also used as an intermediate in the production of dyes and pigments. 4-Pyrid-4-ylbenzoic acid has an aromatic nature and is often used as a reagent in organic synthesis reactions. Overall, this compound plays a crucial role in the manufacturing of various valuable products in the pharmaceutical and chemical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 4385-76-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,8 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4385-76:
(6*4)+(5*3)+(4*8)+(3*5)+(2*7)+(1*6)=106
106 % 10 = 6
So 4385-76-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H9NO2/c14-12(15)11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-8H,(H,14,15)

4385-76-6 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H27882)  4-(4-Pyridyl)benzoic acid, 97%   

  • 4385-76-6

  • 250mg

  • 618.0CNY

  • Detail
  • Alfa Aesar

  • (H27882)  4-(4-Pyridyl)benzoic acid, 97%   

  • 4385-76-6

  • 1g

  • 1590.0CNY

  • Detail
  • Alfa Aesar

  • (H27882)  4-(4-Pyridyl)benzoic acid, 97%   

  • 4385-76-6

  • 5g

  • 4701.0CNY

  • Detail

4385-76-6Relevant articles and documents

Mesomorphic properties of 4-(4-pyridyl)-benzoic acid esters

Adomeniene, Ona,Adomenas, Povilas,Gleiznys, Antanas,Poloudina, Lidija,Gotoh, Yasuyuki

, p. 75 - 79 (2001)

Formerly unknown 4-(4-pyridyl)benzoic acid was synthesized and some of its esters were prepared, their mesomorphic properties were examined. Alkyl-esters of the said acid are nonmesomorphic, while three-ring aryl esters form monotropic smectic A state. Esters aren't stable, they hydrolize easily.

Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors

Bi, Xiaoyang,Chen, Yu,Sun, Zhongya,Lu, Wenchao,Xu, Pan,Lu, Tian,Ding, Hong,Zhang, Naixia,Jiang, Hualiang,Chen, Kaixian,Zhou, Bing,Luo, Cheng

supporting information, (2020/09/16)

CBP bromodomain could recognize acetylated lysine and function as transcription coactivator to regulate transcription and downstream gene expression. Furthermore, CBP has been shown to be related to many human malignancies including acute myeloid leukemia. Herein, we identified DC-CPin734 as a potent CBP bromodomain inhibitor with a TR-FRET IC50 value of 19.5 ± 1.1 nM and over 400-fold of selectivity against BRD4 bromodomains through structure based rational drug design guided iterative chemical modification endeavoring to discover optimal tail-substituted tetrahydroquinolin derivatives. Moreover, DC-CPin734 showed potent inhibitory activity to AML cell line MV4-11 with an IC50 value of 0.55 ± 0.04 μM, and its cellular on-target effects were further evidenced by c-Myc downregulation results. In summary, DC-CPin734 showing good potency, selectivity and anti AML activity could serve as a potent and selective in vitro and in vivo probe of CBP bromodomain and a promising lead compound for future drug development.

PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)

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Page/Page column 202, (2011/07/07)

The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.

Chemical Compounds

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Page/Page column 11, (2008/12/08)

There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy, C1-4alkoxycarbonyl, C1-4alkylsulfonyl and a group R3R4NSO2 (wherein R3 and R4 are independently hydrogen or C1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-4alkyl, C1-4alkanoyl, C1-4alkoxy, haloC1-4alkyl, haloC1-4alkoxy, aryl, aryloxy and C1-4alkoxycarbonyl; and X is indazolyl, pyrazolyl or a group: wherein G is CH or N; and Y1 and Y2 are independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, C1-6alkyl or C2-6alkenyl).

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