9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide

Base Information

• Chemical Name: 9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide
• CAS No.: 894777-42-5
• Molecular Formula: C₂₅H₂₃ClN₄O₂
• Molecular Weight: 446.936
• Mol file: 894777-42-5.mol

Synonyms:9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide

Chemical Property of 9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide

There total 1 articles about 9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-chloro-4-acridinecarbonyl chloride (89459-22-3) + 1-(4-aminobutyl)-3-phenylurea hydrochloride → 9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide (894777-42-5)

Guidance literature:

1-(4-aminobutyl)-3-phenylurea hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

9-chloro-4-acridinecarbonyl chloride; In dichloromethane; at 0 ℃;

DOI:10.1021/jm060035v

Reference yield:

9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide (894777-42-5) → 9-[2-(1,3-dimethyl-thioureido)-ethylamino]-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide

Guidance literature:

Multi-step reaction with 3 steps

1.1: phenol / 0.5 h / 60 °C

1.2: 2 h / 120 °C

2.1: aq. HCl; AcOH / 1.5 h / 20 °C

3.1: ethanol / 8 h / Heating

With hydrogenchloride; acetic acid; phenol; In ethanol;

DOI:10.1021/jm060035v

Reference yield:

9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide (894777-42-5) + (2-aminoethyl)methylcarbamic acid tert-butyl ester (121492-06-6) → methyl-(2-{4-[4-(3-phenyl-ureido)-butylcarbamoyl]-acridin-9-ylamino}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:

9-chloro-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide; With phenol; at 60 ℃; for 0.5h;

(2-aminoethyl)methylcarbamic acid tert-butyl ester; at 120 ℃; for 2h;

DOI:10.1021/jm060035v

upstream raw materials:

9-chloro-4-acridinecarbonyl chloride

Downstream raw materials:

9-(2-methylamino-ethylamino)-acridine-4-carboxylic acid [4-(3-phenyl-ureido)-butyl]-amide